Chest radiological patterns predict the duration of mechanical ventilation in children with RSV infection.

BACKGROUND: RSV-infected children demonstrate various radiographic features, some of which are associated with worse clinical outcomes. OBJECTIVE: To investigate whether specific chest radiological patterns in RSV-infected children with acute respiratory failure (ARF) in the peri-intubation period are associated with prolonged duration of mechanical ventilation. MATERIALS AND METHODS: We included RSV-infected children <1 year of age admitted with ARF from 1996 through 2002 to the pediatric intensive care unit at Massachusetts General Hospital. Their chest radiographs were evaluated at three time-points: preintubation (day -1) and days 1 and 2 after intubation. Univariate and multiple logistic regressions models were utilized to investigate our objective. RESULTS: The study included 46 children. Using day 1 chest radiograph findings to predict duration of mechanical ventilation of >8 days, a backward stepwise regression arrived at a model that included age and right and left lung atelectasis. Using day 2 chest radiograph results, the best model included age and left lung atelectasis. A model combining the two days' findings yielded an area under the ROC curve of 0.92 with a satisfactory fit (P = 0.95). CONCLUSION: Chest radiological patterns around the time of intubation can identify children with RSV-associated ARF who would require prolonged mechanical ventilation.

Respiratory viruses in hospitalized children with acute lower respiratory tract infections, Mazandaran Province, Iran.

We conducted this study to determine the contribution of respiratory viruses in 202 hospitalized children (1 mo-5 yr) with clinical evidence of acute lower respiratory tract illness (ALRI). Nasopharyngeal specimens were assayed for viruses detection by indirect immunoflourescent method. Viral agents were identified from 109 (54%) cases (9 cases had dual infection). The most commonly detected virus was parainfluenza virus 3 in 32 (15.8%) cases followed by respiratory syncytial virus 26 (12.9%) parainfluenza 1 and parainfluenza 2 each 13 (6.4%) influenza A 16 (7.4%), influenza B; 7(3.5%), and adenovirus 12 (5.9%). There were no demographic, clinical, radiologic or laboratory parameters except for recurrent wheeze (OR: 4.47; (95% CI: 1.98-10.73) and fever (OR: 3.27; (95% CI: 1.73-6.20), which could differentiate between patients with or without viral etiology.

[Neonatal hospitalization through a hospital emergency service in Uruguay]. / Hospitalización neonatal desde el servicio de urgencias en un centro hospitalario de Uruguay.

OBJECTIVE: To determine the prevalence of neonatal admissions through a pediatric emergency department (PED), and to evaluate the characteristics of patients who present vital risk on arrival. METHODS: We performed a descriptive, retrospective review of neonates aged 2-28 days arriving from home who presented to the pediatric emergency department between 01/01/03 and 31/12/03. RESULTS: Of a total of 943 neonatal consultations, 277 (29.3 %) required admission. The most common diseases were respiratory (42.6 %) and fever without source (17 %). Among the 943 patients attended, 42 (4,5 %) showed vital risk, and in this group, 81 % were full term neonates, with a P50 of age of 19 days, and a P50 of weight of 3200 g. Among these, there was a predominance of infectious diseases (74 %), especially respiratory tract infections (50 %). Respiratory syncytial virus (RSV) was identified in 14 of the 42 patients. Thirty-six percent required mechanical ventilation and 71.5 % were transferred to the pediatric intensive care unit. Sixty percent of the critically-ill neonates were admitted in the 3 winter months (p < 0.001). CONCLUSIONS: A high percentage of the neonates arriving from home required admission, and vital risk was more frequent in this age group than in other ages (p < 0.001). This does not correspond to risk related to perinatal pathology, or to nutritional reasons, but to community-acquired infections, particularly those of the respiratory tract, the most frequent cause of which is RSV.

Hospitalización neonatal desde el servicio de urgencias en un momento hospitalario de Uruguay / Neonatal hospitalization through a hospital emergency in Uruguay

Objetivo: Determinar la prevalencia de admisiones de recién nacidos a través de un servicio de urgencias pediátricas y evaluar las características de aquellos que a su llegada presentan riesgo vital. Métodos: Estudio descriptivo, retrospectivo, de niños entre 2 y 28 días procedentes del domicilio que consultaron en urgencias pediátricas entre el 1 de enero de 2003 y el 31 de diciembre de 2003. Resultados: Sobre un total de 943 consultas, requirieron admisión 277 (29,3 %). Las enfermedades más frecuentes fueron la respiratoria (42,6 %) y la fiebre sin foco (17 %). Entre los 943 pacientes que consultaron, 42 (4,5 %) presentaban riesgo vital y en este grupo el 81 % eran recién nacidos a término, con un P50 de edad en 19 días y un P50 de peso en 3.200 g. Entre ellos predominaron las enfermedades infecciosas (74 %), en particular las respiratorias (50 %). Se detectó virus respiratorio sincitial (VRS) en 14 de los 42 pacientes. El 36 % requirió asistencia ventilatoria mecánica y el 71,5 % fue derivado a cuidados intensivos o intermedios. El 60 % de los recién nacidos graves consultó en los 3 meses de invierno (p < 0,001). Conclusiones: Los recién nacidos procedentes del domicilio tienen una tasa de ingresos muy alta y presentan riesgo vital con más frecuencia que en otras edades (p < 0,001). Esto no parece responder a riesgos vinculados a patología perinatal o a razones nutricionales, sino a infecciones adquiridas fuera del hospital, en particular de tipo respiratorio, en las que el agente más frecuente es el VRS

Objective: To determine the prevalence of neonatal admissions through a pediatric emergency department (PED), and to evaluate the characteristics of patients who present vital risk on arrival. Methods: We performed a descriptive, retrospective review of neonates aged 2-28 days arriving from home who presented to the pediatric emergency department between 01/01/03 and 31/12/03. Results: Of a total of 943 neonatal consultations, 277 (29.3 %) required admission. The most common diseases were respiratory (42.6 %) and fever without source (17 %). Among the 943 patients attended, 42 (4,5 %) showed vital risk, and in this group, 81 % were full term neonates, with a P50 of age of 19 days, and a P50 of weight of 3200 g. Among these, there was a predominance of infectious diseases (74 %), especially respiratory tract infections (50 %). Respiratory syncytial virus (RSV) was identified in 14 of the 42 patients. Thirty-six percent required mechanical ventilation and 71.5 % were transferred to the pediatric intensive care unit. Sixty percent of the critically-ill neonates were admitted in the 3 winter months (p < 0.001). Conclusions: A high percentage of the neonates arriving from home required admission, and vital risk was more frequent in this age group than in other ages (p < 0.001). This does not correspond to risk related to perinatal pathology, or to nutritional reasons, but to community-acquired infections, particularly those of the respiratory tract, the most frequent cause of which is RSV

Recent trends in severe respiratory syncytial virus (RSV) among US infants, 1997 to 2000.

OBJECTIVES: To provide current estimates of the incidence, associated risk factors, and costs of severe respiratory syncytial virus (RSV) infections among infants in the United States, defined as emergency department (ED) visits, hospitalization, and death. STUDY DESIGN: Retrospective analysis of National Hospital Ambulatory Medical Care Survey data 1997 to 2000; National Hospital Discharge Survey data 1997 to 2000; Perinatal Mortality Linked Files 1998 to 1999. The Hospital Cost Utilization Inpatient Sample data 1997 to 2000 were used to estimate hospitalization costs, and the 2001 Medicare fee schedule was used to estimate ED visit costs. Census data were used for population estimates. Between 1997 and 2000, there were 718,008 ED visits by infants with lower respiratory infection diagnoses during the RSV season (22.8/1000), and 29% were admitted. Costs of ED visits were approximately 202 million US dollars. RSV bronchiolitis was the leading cause of infant hospitalization annually. Total hospital charges for RSV-coded primary diagnoses during the 4 years were more than 2.6 billion US dollars. An estimated 390 RSV-associated postneonatal deaths occurred in 1999. Low birth weight and prematurity significantly increased RSV-associated mortality rates. CONCLUSIONS: RSV is a major cause of infant morbidity and mortality. Severe RSV is highest among infants of black mothers and Medicaid-insured infants. Prematurity and low birth weight significantly increase RSV mortality rates.

Effect of prematurity on respiratory syncytial virus hospital resource use and outcomes.

OBJECTIVES: To determine if gestational age (GA) is independently associated with hospital resource use and outcomes among infants hospitalized for respiratory syncytial virus (RSV). STUDY DESIGN: Analysis of retrospective data from 304 infants ( or =37 weeks) and 89 infants with GA <37 weeks, divided according to GA into 3 subgroups (< or =32, 33 to 35, and 36 weeks), were compared. Significant differences were found for rate of intubation (P=.002) and ICU and hospital length of stay (P=.021 and P<.0001, respectively), with the highest resource use in 33 to 35 weeks GA infants, which remained significant in multiple regression analyses. CONCLUSIONS: Infants 33 to 35 weeks GA had hospital outcomes that were negative or worse than infants < or =32 weeks GA. Data suggest prematurity < or =35 weeks GA significantly increases the risk for severe outcomes among infants hospitalized for RSV. Infants 36 weeks GA had outcomes similar to term infants. No evidence was observed of gradation or inverse linear risk relation between GA and hospital outcomes.

Complications in infants hospitalized for bronchiolitis or respiratory syncytial virus pneumonia.

OBJECTIVE: To characterize complications among infants hospitalized for bronchiolitis or respiratory syncytial virus (RSV). STUDY DESIGN: Retrospective data from 684 infants with bronchiolitis or RSV pneumonia, < or =1 year old, admitted to 10 children's hospitals from April 1995 to September 1996. Outcomes included complication rates and effects on hospital and pediatric intensive care unit (PICU) length of stay (LOS) and hospital costs. RESULTS: Most infants (79%) had one or more complication, with serious complications in 24%. Even minor complications were associated with significantly longer PICU and hospital LOS and higher costs (P<.001). Respiratory complications were most frequent (60%), but infectious (41%), cardiovascular (9%), electrolyte imbalance (19%), and other complications (9%) were common. Complication rates were higher in former premature infants (87%), infants with congenital heart disease (93%), and infants with other congenital abnormalities (90%) relative to infants without risk factors (76%). Infants 33 to 35 weeks gestational age (GA) had the highest complication rates (93%), longer hospital LOS, and higher costs (P<.004) than other former premature infants. CONCLUSIONS: Complications were common in infants hospitalized for bronchiolitis or RSV pneumonia and were associated with longer LOS and higher costs. Former premature infants and infants with congenital abnormalities are at significantly greater risk for complications. Broader use of RSV prevention should be considered for these higher-risk infants.

Morbidity and mortality after RSV-associated hospitalizations among premature Canadian infants.

OBJECTIVE: To evaluate the impact of respiratory syncytial virus (RSV) infections on subsequent health care resource utilization in preterm infants. STUDY DESIGN: Analysis of data from 2415 preterm infants (32 to 35 weeks gestational age [GA]) hospitalized for proven or probable RSV and matched to 20,254 control infants. RESULTS: Mean (SD) age at the index admission was 7.7 (5.5) months; 46% of the infants were male. Mean (SD) subsequent health services, excluding the index event, for the RSV cohort and control infants, respectively, were hospitalization, 2.96 (2.81) versus 1.28 (1.42); special care unit visits, 0.67 (1.70) versus 0.40 (0.33); respiratory therapy visits, 0:31 (0.70) versus 0.13 (0.37); physician consults, 3.61 (4.54) versus 0.89 (1.12); in-hospital procedures, 1.05 (4.02) versus 0.81 (1.51); outpatient visits, 18.4 (10.58) versus 7.54 (4.31); and mean (SD) inpatient days, 14.71 (18.69) versus 5.04 (7.09). All differences were statistically significant (P<.001). Diagnoses for the RSV and control cohorts were respiratory conditions (64% versus 13%), fever (2.7% versus 0.7%), anorexia (2.2% versus 0.6%), lack of normal physiological development (2.8% versus 1.1%; P<.05), overall deaths (8.1% versus 1.6%; P<.001), and sudden death (6.1% versus 0.3%; P<.001). CONCLUSIONS: RSV hospitalization in healthy premature infants is associated with a significant increase in subsequent health care resource utilization and mortality. Results support prophylaxis of premature infants against RSV hospitalization.

Rates of hospitalization for respiratory syncytial virus infection among children in medicaid.

OBJECTIVE: To determine rates of hospitalization associated with respiratory syncytial virus (RSV) infection among children with and without specific medical conditions. STUDY DESIGN: Retrospective cohort study of all children <3 years old enrolled in the Tennessee Medicaid program from July 1989 through June 1993 (248,652 child-years). RESULTS: During the first year of life, the estimated number of RSV hospitalizations per 1000 children was 388 for those with bronchopulmonary dysplasia, 92 for those with congenital heart disease, 70 for children born at < or = 28 weeks' gestation, 66 for those born at 29 to <33 weeks, 57 for those born at 33 to <36 weeks, and 30 for children born at term with no underlying medical condition. In the second year of life, children with bronchopulmonary dysplasia had an estimated 73 RSV hospitalizations per 1000 children, whereas those with congenital heart disease had 18 and those with prematurity 16 per 1000. Overall, 53% of RSV hospitalizations occurred in healthy children born at term. CONCLUSIONS: Children with bronchopulmonary dysplasia have high rates of RSV hospitalization until 24 months of age. In contrast, after the first year of life, children with congenital heart disease or prematurity have rates no higher than that of children at low risk who are <12 months old.

Respiratory syncytial virus immune globulin for prophylaxis against respiratory syncytial virus disease in infants and children with congenital heart disease. The Cardiac Study Group.

OBJECTIVE: To examine the effectiveness of respiratory syncytial virus immune globulin administered intravenously (RSV-IGIV) in reducing hospitalization for treatment of RSV in children with congenital heart disease (CHD). METHODS: Children younger than 4 years of age were randomly assigned to a treatment group receiving RSV-IGIV, 750 mg/kg, monthly or to a control group not receiving infusions. Surveillance for respiratory tract infections was carried out and management decisions were made by physicians blinded to treatment group. RESULTS: Hospitalization for treatment of an RSV infection occurred in 32 of 214 (15%) of control children and 21 of 202 (10%) of the children receiving RSV-IGIV, a 31% reduction (P = .16). However, in infants younger than 6 months of age at study entry, 20 of 82 (24%) in the control group and 10 of 96 (10%) in the RSV-IGIV group had RSV hospitalizations (58% reduction, P = .01). The incidence of hospitalization for any respiratory tract symptomatology was lower in the RSV-IGIV group (34 of 202, 17%) than in the control group (57 of 214, 27%; P = .02). There was a significantly higher frequency of unanticipated cyanotic episodes and of poor outcomes after surgery among children with cyanotic CHD in the RSV-IGIV group (22 of 78, 28%) than in the control group (4 of 47, 8.5%; P = .009). CONCLUSION: RSV-IGIV should not be used for prophylaxis of RSV disease in children with cyanotic CHD. RSV-IGIV did not reduce RSV hospitalization in all children with CHD, but it was effective in preventing RSV hospitalization in infants younger than 6 months of age. Further studies in these children are indicated.

Reduction of respiratory syncytial virus hospitalization among premature infants and infants with bronchopulmonary dysplasia using respiratory syncytial virus immune globulin prophylaxis. The PREVENT Study Group.

OBJECTIVE: To determine the safety and efficacy of monthly prophylaxis with respiratory syncytial virus immune globulin, intravenous (RSV-IGIV) for reduction of the incidence of RSV-associated hospitalization. METHODS: A randomized, double-blind, placebo-controlled clinical trial was conducted at 54 centers in the United States during the 1994 to 1995 RSV season. A total of 510 children with bronchopulmonary dysplasia and/or a history of prematurity were randomized to receive either 750 mg/kg RSV-IGIV (n = 250) or placebo (1% albumin; n = 260) intravenously every 30 days. Randomized groups were well balanced at entry for demographics, RSV risk factors, and birth characteristics. Children were monitored for adverse events and for RSV-associated hospitalization from randomization through 30 days after the last infusion visit; serious adverse events were monitored for an additional 30 days. For children hospitalized with RSV, data were collected regarding the total days of RSV stay, total days of increased oxygen requirement, total days with a moderate or severe lower respiratory tract illness, and frequency and duration of intensive care unit stay and mechanical ventilation. Ninety-five percent of participants completed the protocol and 85% received a complete course of infusions. RESULTS: The incidence of RSV hospitalization was reduced by 41% in children receiving RSV-IGIV prophylaxis; 35 (13.5%) of the children in the placebo group were hospitalized for RSV, compared with 20 (8.0%) RSV-IGIV recipients. RSV-IGIV recipients had a 53% reduction in the total number of RSV hospital days per 100 children, a 60% reduction in the number of RSV days with increased oxygen requirement, and a 54% reduction in the number of RSV hospital days with a moderate or severe lower respiratory tract illness. In addition, children receiving RSV-IGIV had a 38% reduction in hospitalization for respiratory illness of any cause and a 46% reduction in total hospital days for respiratory illness per 100 children. RSV-IGIV was safe and well tolerated, with a safety profile similar to other IGIV preparations. Between 1% to 3% of children had medically significant adverse events related to RSV-IGIV administration. CONCLUSIONS: Monthly administration of 750 mg/kg of RSV-IGIV was safe and well tolerated and was effective in reducing the incidence and total days of both RSV hospitalization and overall respiratory hospitalization in infants with a history of prematurity or bronchopulmonary dysplasia or both.